Response Surface Design (Design-Expert 6.0.5) was used in the experimental design for investigating the influence of liquid PF (LPF) resin viscosity (90, 180, 270 cps), powder PF (PPF) resin particle size in terms of grinding time (0, 15, 30 min), and LPF/PPF combination ratio (25/75, 50/50, 75/25) on strand board performance. Response Surface Analysis suggests a significant quadric model for predicting wet modulus of rupture (MOR) and water absorption (WA) properties. A barely significant linear model was established to predict IB strength. No significant models could be established for dry MOR, dry modulus of elasticity (MOE), MOR retention, and thickness swelling (TS) properties. Response Surface Optimization suggests that the optimal IB, wet MOR, and WA would be 0.59 MPa, 16.9 MPa, and 33.0%, respectively, with 270 cps, 30 minutes, and 25/75 for the optimal resin viscosity, powder grinding time, and LPF/PPF ratio. Resin viscosity, powder grinding time, and LPF/PPF ratio do not significantly influence dry MOR, dry MOE, MOR retention, and TS properties. This study also implies that reducing powder particle size can improve resin efficiency in terms of increased resin coverage and uniform distribution.