The overall objective of this study is to provide information to building design practitioners that will help to improve accuracy of hygrothermal models and enable them to better use these models to predict the durability and thermal performance of wood-based building envelopes. To achieve this, hygrothermal models using WUFI Pro software are validated with experimental data obtained from five wood-frame wall assemblies, with different insulation and vapour control strategies, exposed to the climatic conditions of Vancouver from October 2018 to May 2020. This exercise provides a set of model input parameters that the practitioner can use to assess similar structures exposed to similar environmental conditions. Sensitivity analysis is conducted on the model input parameters to establish which are the most important in obtaining a good fit to experimental measurements, and therefore accurate prediction of assembly performance. There is also discussion on limitations of the hygrothermal model.