The transition of the wood preservatives industry from metal-based preservatives to carbon-based preservative systems requires the development of new analytical techniques. Liquid Chromatography/Mass Spectrometry (LC/MS) is a key method for the identification and quantification of most carbon-based wood preservatives and their degradation products. To enhance our capability to measure these preservatives, a system was needed that could detect low concentrations of preservatives, ionize all compounds of interest, and provide extensive qualitative information. The LTQ XL LC/MS from ThermoFisher was identified as the system best able to meet these needs. This instrument was purchased and installed and methods were developed to separate and quantify three carbon-based preservatives commonly used in emerging wood preservative formulations.