Ten varieties of hybrid poplars from 7 year-old to 30 year-old plantations were evaluated for OSB production. The clones were chosen for their similarity with aspen as well as their impressive growth. Static bending tests on small solid wood speciments indicate that all poplar hybrids have lower modulus of rupture (MOR) and modulus of elasticity (MOE) than aspen. Although the hybrid poplar varieties evaluated in this study generally had physical characteristics similar in aspen and the properties of the OSB panels made from them were good, manufacture of OSB using substantial quantities of hybrid poplar (i.e. 25% or more) will likely require adjustments to some processing steps.